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Transition from the polyp stage to the medusa stage occurs through strobilation, an orderly developmental process of metamorphosis in which transverse constrictions subdivide the polyp body from the oral to the aboral end into segmental discs.
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How this recursive circuitry is extinguished in an orderly manner to enable developmental progression and eventual lineage commitment is currently unclear.
The expression of a primary cilium relies on two main events: 1) activation of ciliogenesis and 2) orderly progression through a series of developmental stages so that a structurally and functionally competent mature cilium is formed [ 27- 29].
Chlamydiae possess an intracellular developmental cycle defined by the orderly interconversion of infectious, metabolically inactive elementary bodies (EBs) and noninfectious, dividing reticulate bodies (RBs) [ 1].
We thus propose that predictable, orderly, and durable tissue regeneration should be based on a "developmental RE-engineering" paradigm, with the challenge to instruct the execution of developmental programs in the context of an adult system.
Wild type-looking GCs of FAMALGK plants re-iterate the stomatal developmental pathway, undergo further divisions and exhibit correct orderly expression of stage-specific stomatal regulators and cell cycle genes.
Hence, orderly function of SNF2 family enzymes is crucial for the execution of normal blood cell developmental program, and defects in chromatin remodeling caused by mutations or aberrant expression of these proteins may contribute to leukemogenesis.
Moreover, loss of this protein may not be sufficient to deregulate the orderly progression of the cell cycle, as mice unable to express pRb2 do not exhibit any altered tumour predisposition or developmental defects [ 3].
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His orderly, Pfc.
It is orderly.
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CEO of Professional Science Editing for Scientists @ prosciediting.com