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In four out of ten runs the model population ended with one fixed mutation at a locus and in three cases with two fixed mutations With both the quadratic and truncation forms of synergistic epistasis, when α is approximately larger than 2, the overall ordering of fitness relationships between sexuals and asexuals remains unaltered.
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Initially, the whole population (in increasing order of fitness) is divided into three groups –- Inferior Group, Mid Group and Superior Group.
The GOLDscore scoring function was used to rank the ligands in order of fitness.
The GOLD scoring function was used to rank the ligands in order of fitness.
The order of fitness of the model is [entropy model > Prelec's weight function > general hyperbolic function > simple hyperbolic function].
The rank order of fitness is well predicted (Spearman's correlation coefficients around 0.5). Figure 2C shows that fitness rankings improve with increasing mutation rates.
The Goldscore scoring function was used to rank the ligands in order of fitness to generate the best poses of the ligand in the active site.
In the light of this result, it is instructive to consider what order of fitness advantage is bestowed by driver mutations within tumours.
> Finally, following an elitist approach, the resulting chromosomes as well as the chromosomes of the initial population are sorted in descending order of fitness.
Figure 12 shows the convergence of the module algorithm for four experiments based on the mean fitness reached by 10 separate runs of the search approach, in order to exemplify the entire range of fitness values.
The experiments were chosen based on the mean fitness reached by 10 separate runs of each search approach, in order to exemplify the entire range of fitness values reached for GPL17.
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