The structural model is described by where kout_MPG, kin_HbA1c, and kout_HbA1c are parameters characterizing the first-order turnover of MPG and HbA1c, respectively.
Using a logarithmic transformation, the first order protein turnover rate (slope) is determined by linear regression.
Using a logarithmic transformation, the first-order protein turnover rate (slope) was determined by linear regression (Fig. S2B).
hRFC transcripts were normalized to hGAPDH as hGAPDH transcript levels did not significantly change over 10 h in the presence of actinomycin D. Normalized hRFC transcripts levels were plotted on semi-logarithmic plots versus time for calculations of first-order transcript turnover rates and half-lives [ 18].
At enzyme concentrations exceeding 3 μM, the observed rate constant for cleavage of HP21 RNA plateaued at a first-order single-turnover rate constant k2 = 0.022 s-1.
At saturating enzyme concentrations Ire1KR32(R1039A) achieved the same first-order single-turnover rate constant k2 as did wild-type Ire1KR32, indicating that R1039 makes no contribution to stabilization of the transition state.
Some general managers and sommeliers receive deferred cash bonuses, à la Wall Street, in order to reduce turnover.
The startup's long-term goal is to help teachers find jobs they like in order to reduce turnover in the U.S. educational system.
Firms would tend to pay a premium to workers benefiting from specific training in order to reduce turnover and therefore avoid losing the investment made (which becomes a type of sunk cost)17.
In order to lower turnover rates, it's important for businesses to ensure that they are hiring the best candidates for the job, individuals who will be more likely to stay and grow with the company for an extended period.
