In order for substantial parts of a genome to be affected, many sites would have to be evolving under such weak selective forces.
Secondly, intervention effects must be maintained over a prolonged period of time in order for substantial health benefits to be realised, though these may continue to accumulate after the end of the intervention.
An important finding from this study is that interventions, or intervention effects in terms of behavioural changes resulting from intervention, must be maintained over prolonged periods of time in order for substantial health benefits to accumulate.
Immunostaining of FSHD myotubes revealed that the fraction of DUX4+ nuclei increased from 0.3%to2.1%1% following UPF1 KD, a substantial order-of-magnitude increase.
Increases in the scale of operations are necessary in order to take advantage of substantial economies of scale.
In a produce-to-order environment, it is of substantial interest to be able to quote a tight and reliable lead time for a new job (or order) upon its arrival to a manufacturing system.
Her story encircles around the strenuous travels she has had to commit to in order to reach some sort of substantial medical facility, which usually only consist of three doctors and three nurses while also being overcrowded with patients; her nearest hospital is a two-hour bus ride away.
In order to avoid the problem of substantial variability in published estimates of body mass and length, we pooled studied taxa into appropriate weight/length categories (Table 1).
The SCQ was used to screen for the presence of an ASD, and GARS was used to measure the magnitude of triad symptoms in order to ensure the presence of substantial autistic symptoms.
