Median levels of PLGF, PLGF/sFlt-1 and T-AOC decreased in the order of severity (severe PE < PE < GH < NP; p < 0.0001) whilst sFlt-1, 8-epi-PGF2α and sFlt- 1/PLGF ratio significantly increased in study participants in the order of severity (severe PE > PE > GH > NP; p < 0.0001) (Fig. 1).
This shows an order of severity (from severe to less severe) of classic infantile (group 1), severely affected adults (group 4), childhood onset (group 2), and mildly affected adults (group 3).
Functional effects of variants can be classified into 34 consequences in Sequence Ontology [ 41], which were ranked in the order of severity (more severe to less severe) by Ensembl analysis group [ 40, 42].
Thus, pneumonia was classified in order of severity as very severe pneumonia, severe pneumonia and pneumonia as opposed to the older WHO classification of severe pneumonia, moderate pneumonia and mild pneumonia respectively [ 28].
Infant factors included gender, gestational age, gestational type (singleton or one of twins/triplets), birth order, history of severe neonatal jaundice (requiring phototherapy and/or exchange blood transfusion), record of illness requiring hospital admission before attending BCG clinic and nutritional status.
Recently, both Fitch and S&P mentioned amounts on the order of EUR90-100bn under severe stress.
First, it requires good quality focused ANC for all pregnant women in order to detect cases of severe PE/E, along with increased awareness of danger signs among women and the community.
Out-of-pocket payments at the point and time of health service utilization in order to meet severe shortages of supplies seem to be a generalized and increasing practice in the public sector in Uganda, despite the official policy of abolition of user fees.
In order to reduce the risk of severe perineal trauma, some authors recommend mediolateral episiotomy in order that any extension to the incision does not lacerate the anal sphincter [ 32].
Together with an increased demand for calories related to breastfeeding, this requires careful individual adjustment of insulin doses in order to avoid severe episodes of maternal hypoglycemia [ 18].
