Sentence examples for order of replication from inspiring English sources
High-throughput experiments have enabled genome-wide characterization of the temporal order of replication (Gilbert, 2010).
All human protein-coding genes were sorted according to these median ranks to estimate the temporal order of replication.
The temporal order of replication (replication timing) is linked to many basic cellular processes that are regulated both during the cell cycle and development.
For further analyses we used the order of replication of each gene from the genome-wide RT profiles, as a relative measure of the moment of replication of each human protein-coding gene (see Materials and Methods).
The loss of fidelity in the inherent order of replication of allelic pairs during cell division provides a source for generating mutations involving genetic (aneuploidy) and epigenetic (gene silencing or allelic inactivation) events required for the generation and establishment of malignant phenotype (Duesberg et al, 2000).
We are currently in the process of identifying origins of replication and replicon boundaries in some of these very early replicating regions in order to understand further the processes that orchestrate the order of replication at the beginning of the S phase.
The DNA polymerase inhibitor aphidicolin allows for the initiation of DNA replication, but dramatically slows replication fork progression [ 25, 26] without altering the order of gene replication [ 27].
The method of choice for evaluating the temporal order of allelic replication is the fluorescence in situ hybridization (FISH) replication assay [ 11, 15- 18].
The fluorescence in situ hybridization (FISH) replication assay is the method of choice for evaluating the temporal order of allelic replication [ 11- 14].
Cellular TR mutability might be affected by the temporal order of DNA replication during the S-phase of the cell cycle.
A simple method for evaluating the temporal order of allelic replication utilizes the fluorescent in situ hybridization (FISH) assay (Boggs and Chinault 1997; Dotan et al. 2008).
