In general, simultaneous treatment was more effective than sequential exposure, regardless of the order of dosing, treatment duration or time of exposure.
In models with the radioiodine dose divided into quartiles, the unadjusted odds ratios for the second, third, and fourth quartiles (in order of increasing dose) were 1.04 (95% CI: 0.70, 1.54), 1.64 (95% CI: 1.13, 2.38), and 1.21 (95% CI: 0.82, 1.78), respectively.
The mean APTT for each group following the final nebulisation, in order of increasing dose, was 34 seconds (normal range < 35 seconds), 41 seconds, 48 seconds and 64 seconds (P = 0.09, analysis of variance, comparison by dose).
The mean TCT for each group following the final nebulisation, in order of increasing dose, was 18 seconds (normal range < 21 seconds), 23 seconds, 50 seconds and 48 seconds (P = 0.1, analysis of variance, comparison by dose).
Four repeated measurements of blood volume (BV) were performed in random order of bolus dose (10 mg or 25 mg ICG) and venous administration site (peripheral or central) in eight patients admitted for treatment of an intracranial aneurysm.
If these two data and 〈 R〉φ for DEP (50 μg; not highlighted) are excluded from the regression analysis, the resulting r values improve significantly, but the "order" of the dose parameters changes: 0.90 (particle number), 0.92 (joint length), and 0.96 (BET surface area).
Tables 1 and 2 show, in order of decreasing dosing (washout) interval, the average center frequency of low frequency peaks in the baseline spectral power across EEG channels for Subjects 1 and 2 prior to each administration of zolpidem.
This formulation facilitated gene silencing at orders-of-magnitude lower doses of siRNA than those required by the original SNALP formulation, resulting in reduced toxicity [ 41].
