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The sensitivity analysis indicated that the most important parameters affecting the CSDs are nucleation order and growth order constants.
Depending on these factors, half-lives were in the range: 2 270 h for indomethacine and 3 558 h for diclofenac, equivalent to apparent second order constants between 0.65 and 9.5 M−1 s−1 and 0.27 and 7.4 M−1 s−1, respectively.
(Ho and McKay 1999): frac{t}{{q_{t} }}, = frac{1}{{k_{2} q_{text{e}}^{2} }}, + frac{t}{{q_{t} }} (4 where q e (mg/g), the equilibrium adsorption capacity and K 2 (g/mg min), the second order constants can be calculated using the slope and intercept of the linear fit of the plot t/q t versus t (Fig. 5).
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First order constant k was 0.24 d-1.
A pseudo-first order constant of k = 0.157 ± 0.007 min− 1 has been determined.
The first order constant, as an indicator for substrate biodegradability, reflects the hydrolysis efficiency and metabolic activity.
Two models for 0 order (constant rate) elimination were also fit to the data for comparison of mean square error.
However, simulation results converge very slowly to the steady state (not shown) as the first order constant for receptor synthesis is about 10-17 M· min-1.
Consider (2) log C = log C 0 − K 1 t 2.303, where C0 is the initial concentration of drug and K1 is first order constant.
Pseudo first-order constants fitted with Monod kinetics were later substituted into the transport model.
The linear plots of t/q t versus t which is given in (Fig. 9b) were used to calculate the pseudo-second-order constants.
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