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Based on this, a complete picture on genome organization evolution clearly requires considering the information coming from both core gene order (backbone stability) and insertions/deletions of accessory genes (genome organization stability).
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Was it possible — the tension, the withdrawals, the pillow-muted sobbing behind locked doors, all due to an out-of-order backbone?
Linker residues Asp72PBIP1 and Glu7term also adopt similar solvent-exposed conformations, but only the side chain of Asp72PBIP1 is ordered; the backbone nitrogen atom of this residue forms a hydrogen bond with the hydroxy group of Tyr417PBD.
In binary and ternary complexes of KIX, the three-helix scaffold of the protein is well-ordered in solution, with backbone order parameters of ca. 0.9 for helices α1−α3.
In the liquid-crystalline phase, this strong in-plane ordering of backbones is lost.
Intriguingly, the overwound right-handed SsoRadA filament contains ordered polypeptide backbones and side-chains in two important structural regions, L1 motif (amino acid residues 219 226) and NTD (amino acid residues 14 69), compared to those found in the previous lower resolution P3121 form.
Likewise, the 1489 cm 1 component of the symmetric thiophene C=C stretch derives intensity from ordered PBTTT chains in bimolecular crystals, where side group and backbone order is improved.
However, it is known that confinement of polyethers in pores results in stretching and ordering of the backbone and that such ordering can increase ion conduction.
Judge Rakoff called the contempt power - a judge's ability to punish a party for disobeying a court order - "the backbone of the judiciary".
This guarantees that the backbone order of matched nucleotides as well as base pairs of the given RNAs are preserved.
TALOS-N also derives side-chain χ1 angle information and reports an estimated backbone order parameter S derived from the chemical shifts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com