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Exact(9)
The zero order absorption spectra were recorded against a reagent blank (methanol).
Different absorption models were tested, including first-order absorption, first order absorption with lag time, zero order absorption, sequential zero and first order absorption, and a transit compartment absorption model with 1 10 fixed transit compartments [ 46].
A two compartment model with first order absorption and a lag time described the data adequately.
Plasma drug levels fitted better to the first-order absorption model (R = 0.98, Akaike Information Criterion [AIC] = 8.31), whereas the brain drug levels fitted better to zero order absorption model (R = 0.98, AIC = 6.52).
Tacrolimus pharmacokinetics were best described by a two-compartment model and first order absorption with a lag time.
A zero order absorption model with an absorption lag was also fitted (ADVAN1); both the absorption lag time and absorption duration were allowed to vary across the population.
Similar(51)
It presents the developments of a Zero-Order absorption cycle model simulating vapor Absorption Refrigeration cycle, and a Zero-Order Absorption Cycle model simulating Vapor Absorption Refrigeration cycles.
An oral one-compartment model with first-order absorption adequately described rivaroxaban PK.
The structural model was two-compartment with first-order absorption.
One, two, and three compartment structural models with first-order absorption were tested.
(2) Using a first-order absorption function with a lag time.
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