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For this, we used an approach that detects orchestrated regulation of neighboring enzymes in the metabolic network.
The most important factor that affects normal bone remodelling is the tightly controlled and orchestrated regulation of osteoblasts and osteoclasts.
In contrast, a recent study by Elsharkawy determined a role for HDAC1 in the NF-κB orchestrated regulation of MMP13 expression.
We used Haar Wavelet transforms on optimally arranged grid representations of metabolic pathways as a pattern recognition method to detect orchestrated regulation of neighboring enzymes in the network.
They can play either permissive or instructive roles, and it is likely that there is a strictly orchestrated regulation of all of them, where some could be involved at early stages of aging and others could take effect only at later times, leading to the aging of neurogenic areas.
Orchestrated regulation of enzyme expression in the central region will allow glycan production to be enhanced in specific modules, while avoiding moderately the increased production of other unwanted modules.
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Also, complex signaling pathways can be treated as a tightly connected network that orchestrates regulation of a specific functional behavior, rather than as individual, separate mechanisms by focusing on a specific oncogenic molecule or its activating event alone [14].
These factors orchestrate transcriptional regulation in tune with neuronal responses.
In addition, Snail family proteins collaborate with other transcription factors to orchestrate concerted regulation of EMT.
Our results provide evidence for a comprehensive multi-functional molecular interaction network orchestrating growth regulation and cold acclimation in two natural accessions of Arabidopsis thaliana.
The local tumour/tissue microenvironment with its autocrine and paracrine cytokine signalling networks is bound to orchestrate DC regulation as well as Treg activation and, therefore, is of critical importance for disease progression.
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