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Ring1B is an essential member of the highly conserved Polycomb group proteins, which orchestrate developmental processes, cell growth and stem cell fate by modifying local chromatin structure.
Upon stimulation, an increase in intracellular calcium turns on the serine/threonine phosphatase calcineurin (CaN), which then binds to NFAT and dephosphorylates the protein, causing its nuclear translocation, where they orchestrate developmental and activation programs in diverse cell types.
Large and complex networks of distinct kinds of molecules orchestrate developmental mechanisms.
Type IV collagens can also influence intercellular communication and orchestrate developmental and homeostatic processes by modulating the distribution and bioavailability of diffusible morphogens (67– 71).
More generally, these data reveal that after WGD in the early evolution of vertebrates, paralogous genes encoding key transcriptional regulators maintained some shared roles yet also diverged functionally in evolution to orchestrate developmental complexity and robustness.
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The science of how C. elegans matures is a study of genetically orchestrated developmental programs that activate at specified time points in the animal's existence.
Placental function follows a carefully orchestrated developmental cascade during gestation.
Homeobox genes are an important class of master regulatory genes that encode transcription factors responsible for orchestrating developmental processes in many species of animals, as well as in plants and fungi.
Recently, it has been reported that lncRNAs, including pancRNAs, are frequently regulated by developmentally important factors, such as homeobox proteins, (Necsulea et al., 2014), supporting our idea that pancRNAs acts together with other regulatory factors for complex and orchestrated developmental gene regulation.
A more detailed understanding of the complex changes in gene expression that orchestrate berry developmental processes is needed.
Taken together, conserved miRNAs along with the species-specific miRNAs, in part, orchestrate the developmental progression of B. mori.
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