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Component-based software construction relies on suitable models underlying components, and in particular the coordinators which orchestrate component behaviour.
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Such actions are aspects of coordination, operating to mediate and orchestrate components to meet high-level functional goals.
We show how PTIDES can function as a coordination language, orchestrating components that may be designed and specified using different formalisms.
Cytokines orchestrate other components of the immune system to appropriately fight the invading virus, while chemokines direct these components to the location of infection.
It takes an immense depth of skill to balance and orchestrate those components.
Composing and orchestrating software components is a fundamental concern in modern software engineering.
Understanding how heat shock protein-receptor binding orchestrates individual components of tumor immunity will permit enhanced design of molecular chaperone based immunotherapy.
The target of rapamycin (TOR) has been shown to play a key role in mediating healthspan extension in response to CR by integrating different signals that monitor nutrient-availability and orchestrating various components of cellular machinery in response.
Dynamic interactions among these protein components orchestrate substrate delivery to their diiron centers and subsequent catalytic turnover.
Theoretical study may afford a platform to explore how the different components orchestrate the migration process as a whole.
While FOXC2 orchestrates the mesenchymal component of the EMT program (Mani et al., 2007), Slug, ZEB2, and Twist1 repress E-cadherin expression, a fundamental event in EMT, as well as the expression of proteins of tight junctions, gap junctions, and desmosomes, contributing to the de-differentiated state of tumor cells and facilitating EMT (Peinado et al., 2007; Sanchez-Tillo et al., 2012).
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