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It was orally bioavailable and brain penetrant.
Tse, C. et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor.
Negoro, N. et al. Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.
Trammell, S. A. et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.
Zhang, X. et al. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.
Honma, D. et al. Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor.
Liang, J. et al. From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.
Cross, R. M. et al. Orally bioavailable 6-chloro-7-methoxy-4(1H -quinolones efficacious against multiple stages of plasmodium.
Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.
The purpose of present study was to identify good orally bioavailable calpain inhibitors.
The design and synthesis of highly potent, selective orally bioavailable inhibitors of PDE10A is reported.
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CEO of Professional Science Editing for Scientists @ prosciediting.com