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The study consisted of a screening and washout phase of up to 21 days (including oral tolerability testing with paliperidone extended release [ER] 6 mg/day for 4 to 6 consecutive days for patients without documented previous exposure to risperidone or paliperidone) and a 53-week open-label treatment phase (approximately 56 weeks in total).
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It has good oral bioavailability, tolerability, and crosses blood-brain barrier easily.
This study was designed to evaluate the PK properties, oral bioavailability, and tolerability with a single-dose oral and intravenous administration of tedizolid phosphate in healthy Korean male subjects.
Abiraterone acetate delivers clinically meaningful advantages in its oral administration, favorable tolerability profile, and high efficacy.
Any consideration of antimicrobials for the treatment of PCP must take several factors into consideration: the severity of disease, as determined by hypoxemia (ie, PaO2 < 9.3 kPa or SpO2 < 92% on room air) the need for intravenous versus oral medication the tolerability of the regime and the impact of drug toxicities prior treatment with PCP prophylaxis.
Bucsi L, Poór G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis.
Longbrake, E. E., Cross, A. H. & Salter, A. Efficacy and tolerability of oral versus injectable disease-modifying therapies for multiple sclerosis in clinical practice.
To compare efficacy, satisfaction and tolerability of oral dydrogesterone and micronized vaginal progesterone gel used for luteal supplementation.
In order to evaluate the gastric tolerability after oral administration of PSOQ or meloxicam (10 mg/kg), mice were fasted for 18 h prior to drug exposure.
We assessed the therapeutic efficacy and tolerability of oral potassium supplement dissolved in grape juice in female hypokalemic patients with active RA.
The present global, open-label, single-arm, multicenter, phase IIb study was designed to determine the efficacy and tolerability of oral vorinostat combined with standard doses of bortezomib in patients with multiple myeloma considered refractory to novel myeloma agents.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com