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The dog was treated with oral ketoconazole (10 mg/kg/day) for 5 weeks.
Treatment was initiated with intensive topical amikacin, oral ketoconazole and oral doxycycline.
On study day 15, they received 400 mg oral ketoconazole, followed 90 min later by a 25-mg i.v. dose of diphenhydramine.
Sheep immunosuppression with daily intravenous cyclosporin augmented by oral ketoconazole maintained trough blood levels of cyclosporin within the range 1000-1500 ng ml -1).
Coadministration of 400 mg oral ketoconazole with 5 mg i.v. temsirolimus had no significant effect on temsirolimus maximum concentration (Cmax) or area under the concentration curve (AUC).
The patient did not show improvements after applying topical natamycin (5 %), topical amphotericin B (1mg/ml), topical fluconazole (2mg/ml) and oral ketoconazole (200mg).
Similar(51)
Limited or temporary improvements were reported with oral isotretinoin, ketoconazole, nicotinamide, vitamin A, vitamin B6, vitamin D, and vitamin E [ 17].
Earlier studies conducted by Savino and coworkers [ 64] and Slotman and Burchard [ 63] compared the efficacy of prophylactic administration of oral clotrimazole, ketoconazole, or nystatin with that of placebo in patients selected based either on expected length of stay in the ICU or on baseline risk factors.
The levels of ritonavir in the brain tissues and cerebrospinal fluid (CSF) tend to be low [ 58] when given orally, but can easily be increased from 2.4 to 6.6 ng/mL CSF with oral co-administration of ketoconazole [ 59].
Rapid remission of Tinea pedis from rats treated with OPT-ME formulation was observed in comparison to commercially available therapies (ketoconazole cream and oral itraconazole solution), thereby indicating the superiority of microemulsion hydrogel formulation over conventional approaches for treating superficial fungal infections.
Oral and topical administration of ketoconazole resulted in an up to 73%% inhibition of the activity.
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