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Animals in this study were infected with MCMV intranasally, since the oral, intranasal, and subcutaneous routes can be the natural MCMV infection routes [ 14, 15].
Silica nanoparticles are reported to be distributed to the liver after dermal, oral, intranasal, and intravenous administration [9, 18, 19].
Most opioid abusers tamper with tablets to facilitate oral, intranasal, or intravenous administration, whereas compliant patients usually take intact tablets.
Ketamine is used by oral, intranasal, rectal and subcutaneous routes [ 24].
Most pathogens invade the body via a mucosal pathway: oral, intranasal or vaginal.
Reliable methods of diagnosing ASA sensitivity have been developed and provocation challenges can be done via oral, intranasal, inhaled, and i.v. routes.
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A total volume of 0.5 mL was inoculated through an oral-intranasal route with each duck and chicken dose containing approximately 107.2 median egg infectious doses (EID50) [29].
The statistical difference in absolute bioavailability between oral and intranasal route suggested that intranasal route had almost 21% increases in bioavailability for ZT and for KT there was 16% increase over oral formulations.
Therefore, mucosal vaccination, especially through oral or intranasal administration routes, is highly desired for infectious diseases.
Its efficacy has been demonstrated for the oral and intranasal formulations.
Thus, melatonin-sustained release formulations have been developed for oral [8 14], intranasal [15], transdermal [16 18], and transmucosal [18, 19] administrations.
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