A benefit of such solutions is that the tongue interface device remains hidden to others (intra-oral interface).
We hypothesized that the surface tension at the surface-to-air interface of oral formulations would have a large range, since, upon clinical administration of the medication, the liquids would be quickly distributed throughout the significantly large volume of the GI tract.
Whereas trabecular bone in the edentulous jawbone appears to undergo remodeling processes at a comparative rate with other bones [16], [17], the separate osteoclastic activity is uniquely localized along the external surface of the residual ridge interfacing the oral mucosa [2], [17].
The surface tension at the surface-to-air interface of the oral formulations studied were in or above the range of the surface tension of gastric, duodenum, and jejunum fluids.
Nonetheless, the range of surface tensions at the surface-to-air interface for the oral formulations examined was between 36.6 and 64.7 dynes/cm, or a difference of 28.1 dynes/cm.
As the pellicle is the primary interface between the oral environment and the hard and soft tissue of the mouth it plays an important role in oral physiological and pathological processes (Hannig & Joiner 2006).
This approach offers potential for the clinical implementation of customized periodontal scaffolds that may enable regeneration of multi-tissue interfaces required for oral, dental and craniofacial engineering applications.
The oral mucosa constitutes a critical protective interface between external and internal environments that serves as a barrier to the hundreds of microbial species present in this environment [4], [6].
Oral mucosae are a critical protective interface between external and internal environments and must serve as a barrier to the myriad microbial species present in the mouth.
Multi-tissue scaffolds for oral and dental tissue regeneration at various interface regions in the oral cavity are discussed thoroughly.
Herein, we report our findings on the surface tensions at the surface-to-air interface for a range of oral, nasal, and ophthalmic over-the-counter (OTC) drug substances.
