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In the screening population (TUEF NN = 725), we found a significant association of rs9402571 with glucose-induced insulin secretion in various estimation models based on oral glucose tolerance testing.
Diabetes was diagnosed semiannually by fasting glucose and annually by oral glucose tolerance testing.
The glucose levels in pregnant women would be obtained through oral glucose tolerance testing.
However, the Diabetes Prevention Trial Type 1 Risk Score includes C-peptide and glucose indexes from oral glucose tolerance testing.
Diabetes was defined by physician diagnosis and/or oral glucose tolerance testing with values of 7 mmol/L fasting or 11.1 mmol/L at 2 h.
We describe, for the first time, gradual alteration of glucose homeostasis in a patient with HNF4A mutation after resolution of hyperinsulinaemic hypoglycaemia, on serial oral glucose tolerance testing.
In conclusion, we report the first patient with HNF4A hyperinsulinaemic hypoglycaemia to have switched to maturity-onset diabetes of the young on serial oral glucose tolerance testing.
This register sent a reminder letter at 15 months after birth to women who had experienced GDM to encourage oral glucose tolerance testing.
The control subjects were recruited by advertising in local newspapers, and undiagnosed diabetes was excluded at baseline by fasting glucose and oral glucose tolerance testing.
We describe the first patient with an HNF4A mutation to have been serially monitored with oral glucose tolerance testing through to MODY from hyperinsulinaemic hypoglycaemia.
Future studies should attempt to answer the question whether measurement of glycated hemoglobin will obviate the need for oral glucose tolerance testing.
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