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The aim of the present study was to evaluate the feasibility of clinically applying facial-submental artery island flaps on primary reconstruction of oral floor defects following cancer ablation.
Methods: We used KB cell that an oral floor squamous cell carcinoma, vitamins as all-trans retinoic acid (ATRA), 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), 1α,25(OH)2D3 (calcitriol) and 22-oxa-1,25- OH 2D3 (OCT).
M. mylohyoideus—In most mammals, this muscle forms the oral floor, meeting at a ventral midline raphe.
Patients with histologically proven squamous cell carcinoma of the oral floor treated surgically were eligible for the study.
HIF-1α overexpression is an indicator of favourable prognosis in T1 and T2 SCC of the oral floor.
Clinical and tumour details of the 85 patients with oral floor squamous cell cancer are shown in Table 1.
Similar(36)
Primary tumour sites included oral cavity (floor of mouth, tongue, retromolar trigone, and alveolar ridge, n=16), pharynx (soft palate, base of tongue, and posterior wall of pharynx, n=6), and larynx (aryepiglottic fold, glottis, epiglottis, subglottic, and transglottic, n=18).
To examine the effects of nisin, an oral cancer floor-of-mouth mouse model was used.
The oral tongue and floor of the mouth are rich in lymphatics and tumours in these areas have a higher risk of nodal metastases compared with the hard palate and alveolar ridge.
To be included in the study, patients must be over 18 years of age and have a cancer of the oral cavity (tongue, floor of the mouth, gums, palate and inside of the cheeks), of the oropharynx (tonsils, root of the tongue and soft palate) or of the hypopharynx and larynx (supraglottis, glottis and subglottis).
These patients included a 39 year old man with ulcerating eosinophilic granulomatous inflammation that produced extensive soft tissue infiltration that narrowed the nasopharynx and involved the oral cavity including the floor of the mouth, base of the tongue, supraglottis, and glottis.
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