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QSAR analyses were performed on the available 68 IC50 oral data based on theoretical molecular descriptors.
Both intravenous data and oral data were accepted.
Indeed, i.v. and oral data matched with Toulouse and Rotterdam HPLC measurements, respectively.
Subsequently, rich sampled oral data (days 1 and 2) were evaluated to construct the best performing absorption model.
This design has the advantage that CsA bioavailability could be estimated, since intravenous and oral data were analyzed simultaneously.
Estimating the absolute oral bioavailability, and thereby the absolute value of clearance, reduced the risk of biased estimates of apparent nonrenal clearance when only oral data were available.
Similar(44)
Disposition parameters were estimated by fitting compartmental models to the oral PK data, since intravenous data are not available for celecoxib.
The information sought was related to (a) children and adolescents, (b) oral health data, and (c) routines for registering such data.
The modeling of oral health data is rather complex, since these data generally do not present normal distribution.
Questionnaire and oral health data were entered into an Excel data base using double entry to check for accuracy.
Approximately one-fourth of the target population had comprehensive oral examination data available during the 5-year data collection time frame.
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