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To minimise batch variation, each batch was run with equal numbers of OSCC, oral controls, PSCC and pharyngeal controls.
One thousand eight hundred eighty-three genes were differentially expressed between oral cancer and oral controls with an adjusted P-value (FDR q<0.05, P<0.007, variance 0.07).
From the miRNA that changed more than fivefold up or down between OSCC and oral controls, we found 452 predicted target genes, which had a combined weighted inhibitor score of more than 2/−2.
The most differentially regulated miRNAs in this study was miR-375, which was highly expressed in oral controls and almost absent in the OSCCs, but the difference between cancer and control was much less pronounced in the pharynx.
Many of the miRNAs lost in oral cancers and highly expressed in oral controls were more highly expressed in the pharyngeal cancers and only slightly higher expressed in the pharyngeal controls, indicating a higher resemblance in miRNA profile of pharyngeal epithelium with cancer.
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Oral controlled drug delivery systems have become an essential part of the development of new medicines.
Mirabegron is formulated as an extended-release tablet using oral controlled-absorption system (OCAS) technology.
In conclusion, a novel, oral, controlled-release delivery system for tamsulosin hydrochloride was successfully developed by incorporating HPMC and HPMCP as coating additives into Surelease® aqueous ethylcellulose dispersion.
The present study is carried out to design oral controlled drug delivery systems for aspirin using synthesized hydrogels as carrier in form of tablets.
L18 Hunter design was used to investigate the practicability of applying QbD approaches to fluidized hot melt granulation (FHMG) in preparing oral controlled release systems.
Oral controlled release products provide several lucrative advantages over conventional dosage forms by maximizing the pharmacokinetic and pharmacodynamic traits of drugs.
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