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Median time to progression of CMV retinitis is 12 20 days shorter with oral compared to IV ganciclovir maintenance, likely due to the limited oral bioavailability of ganciclovir.
Oral compared to parenteral estrogen administration is characterized by reduced systemic but prominent hepatic estrogenic effects on lipids, hemostatic factors, GH-/IGF I axis, angiotensinogen.
A secondary objective was to evaluate the cost-effectiveness of oral compared to IV regimen.
Our secondary objective was to study the cost-effectiveness of oral compared to IV alfacalcidol administration in HD.
The overall population showed a tendency not to believe in feeling less ill under oral compared to i.v. treatment.
Moreover, data obtained in trachetomized patients have indicated significant contributions from oral compared to tracheal sources [ 15, 16].
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Overexpression of miR-21 has also been observed in oral premalignant lesions (oral leukoplakia) compared to normal oral mucosa, indicating that alteration in miR-21 could be an earlier event in OSCC progression [ 21].
Moreover, expression of DR4, DR5 and DcR1 are up-regulated in premalignant and malignant oral epithelia compared to normal oral epithelium.
A partial loss of DcR2 expression is also noted in premalignant and malignant oral epithelia compared to normal oral epithelia, and DR5 expression is significantly associated with larger tumor size.
As such, the increase in the expression of hnRNP K was about 56-fold in oral SCC compared to the normal oral epithelium.
PSCA was significantly upregulated in the HPV+ oral tumors compared to the HPV− oral tumors (P = 0.006) in terms of the labeling index (LI), which corresponds to the percentage of immunopositive cells.
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