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Further, it showed higher oral absorption than CFDN and FK041.
Further, it showed higher oral absorption than CFDN.
Here, we aimed to improve exenatide oral absorption by conjugating the specific targeting ligand Fc to the nanoparticle surface.
Sheng, J. et al. Enhancing insulin oral absorption by using mucoadhesive nanoparticles loaded with LMWP-linked insulin conjugates.
This is a worst-case assumption, as for metals dermal absorption is generally lower than oral absorption.
The technology could subsequently be used to enhance the oral absorption of drugs in which the drug dissolution is the rate-limiting process of oral absorption.
The results of oral absorption experiment in mice showed that SMEDDS could significantly increase the oral absorption of curcumin compared with its suspension.
However, much additional research is needed to demonstrate the oral absorption of exenatide, e.g., pharmacokinetic study or the mechanism of transport through Caco-2 cell research.
The oral exenatide solution group also did not show reduced blood glucose levels, demonstrating poor oral absorption of the free exenatide in the small intestine.
Cui, M. et al. Liposomes containing cholesterol analogues of botanical origin as drug delivery systems to enhance the oral absorption of insulin.
The gut-on-a-chip could also be used to test the metabolism and oral absorption of drugs and nutrients.
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