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The mean dosage of indomethacin (25 mg bid or tid) was 59 ± 16 mg, while rofecoxib was administered in a dosage of 50 mg/day; 33 (51%) patients had a complete remission and 19 (22%) showed a partial response.
Three quarters of the patients were on a BID or TID regimen.
The preplanned integrated analysis included patients randomized to receive placebo or DMF BID or TID.
In bid or tid regimens (with or without OADs), weight gain follows a similar range: 0.7 to 5.4 kg.
In DEFINE, patients were randomized to receive DMF 240 mg BID or TID or placebo for up to 96 weeks.
The ITT population for the integrated efficacy analysis comprised 2301 patients randomized to receive placebo (n = 771) or DMF BID (n = 769) or TID (n = 761).
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Typical Spontaneously Contracting hESC Cardiomyocytes on Micropatterned Polyacrylamide in Control Medium or TID-Containing Medium, Related to Figure 4 Movie S2.
Patients received nepafenac or placebo TID beginning 1 day before cataract surgery and continuing on the day of surgery for 14 days.
A total of 2301 patients (ITT population) were randomized and received treatment with placebo (n = 771), DMF BID (n = 769) or DMF TID (n = 761) (Fig. 1).
The integrated analysis was performed on data from the ITT population, which included patients who were randomized and received at least one dose of placebo, DMF BID or DMF TID.
Urea was generally given in 15 or 30 g doses tid or qid, with a median daily dose of 50 g.
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