The lesions are possibly more severe in winter, reflecting functional changes associated with the micro- and macroangiopathy.
When compared to WS, AWS patients appear to develop an earlier onset, more rapid rate of progression and possibly more severe age-related symptoms [ 18].
Furthermore, the dementia of the EOD patients is possibly more severe because establishing a diagnosis in EOD often takes longer than in LOD.
Others used daily data and did not account for a lower level of cycling and possibly more severe weather during night time [ 26, 28- 31, 35].
In this context, a possibly more severe form of bias could be introduced by loss to follow-up, especially if it differs between exposed and unexposed subjects [ 73].
Eidelwein et al. [ 16] reported that pediatric CD was possibly more severe in AAs, often presenting with lower body mass scores, blood sedimentation rates and hemoglobin (Hb).
The mechanism of this phenomenon is unclear, as is the mechanism of possibly more severe hypoglycaemia occurring after cold somatostatin analogue injection in patients with malignant insulinoma.
Members of patient associations are often older, with longer disease duration and possibly more severe disease, as it takes time before they join.
When asked about the instrument's relevance, a substantial portion of the sample provided mixed responses, stating that the EQ-5D could be relevant to other and possibly more severe patients, but not to their own personal experience.
Although the relative contributions of β-cell failure (possibly more severe in Asian populations) and insulin resistance (more severe in Westernized societies with a high prevalence of obesity) may vary among different ethnic groups (37), virtually all adults with type 2 diabetes have some combination of the two.
Table 2 summarizes the few epidemiologic studies of in-traffic air pollution exposures, suggesting that these exposures result in physiologic changes (including airway and systemic inflammation and lung function decrements) in healthy adults and asthmatics and possibly more severe adverse effects (myocardial infarction).
