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A secondary aim was to use additional data collected in this study to update an earlier meta-analysis of the evidence on the effect of an internet option in population studies [ 7].
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While the method is not invalidated by genetic or ecological heterogeneity across populations, in such instances it either requires independent estimates of the probability of each option in each population, which in some instances may be difficult to obtain, or application on a smaller scale, within which such sources of bias do not apply.
We believe that our approach, with simple validated interviewer-administered culturally-validated instruments, was a more practical option in a population with high illiteracy, and it best served our public-health purpose.
As high levels of matAb are known to be protective, maternal vaccination might be another option in this population.
Therefore, economic modelling was not considered a valid option in this population.
25 It is thus a safe and effective short-acting insulin option in this population.
Although it remains a methodological pitfall, proxy reporting is often a valuable option in this population.
Based on our experience, we consider ECLS as a last resort, efficient, and relatively safe therapeutic option in this population.
In patients unable to tolerate MTX, tocilizumab appears to offer a greater likelihood of PRO improvements than aTNF monotherapy and may represent an attractive option in this population.
Incretin-based therapies may be a useful option in this population, which includes patients with moderate-to-severe renal impairment or heart failure.
The second contribution relates to estimating parameters of cerebral oxygen metabolism in preterm neonates on ventilators, which may eventually enable patient-specific treatment options in this population.
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