We recently proposed a 2-stage phase II design that has the option for direct assignment (i.e., stop randomization and assign all patients to the experimental arm in stage 2) based on interim analysis (IA) results.
The Phase II design with an option for direct assignment (i.e. stop randomization and assign all patients to the experimental arm based on a single interim analysis (IA) at 50% accrual) was recently proposed [An et al., 2012].
This demonstrates that in larger RNAs where other NMR approaches (e.g., comparative imino proton approach) meet limitations PRE tagging is an option for fold assignments by NMR.
CIEE Teach Abroad offers options for teaching assignments in Chile, China, South Korea, Spain, Thailand, Vietnam, and the Dominican Republic.
"Chris was out of options so we designated him for assignment.
The team optioned Thomas to triple-A Oklahoma, assigned Jaime to extended spring training and designated Stults for assignment.
In other moves, the right-hander Brian Boehringer was designated for assignment and the right-hander Adrian Hernández was optioned to Columbus.
Roberts, who had been a leading candidate to start this season, was designated for assignment, even though he is out of options.
To clear space on the 25-man roster, the Yankees optioned Dave Robertson to Scranton and designated the minor league pitcher Eric Hacker for assignment.
Robinson immediately wondered if the Nationals would designate him for assignment, because he doesn't have any minor league options remaining.
Perez and Walker Cut The Mets set their 25-man roster, optioning outfielder Timo Perez to Class AAA Norfolk, reassigning pitcher Pete Walker and designating outfielder Chris Latham for assignment.
