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The influence of the temperature and recyclability of the optimum samples were studied.
Based on previous experiments with commercial microspheres, three optimum samples were selected for further investigations.
Further studies are recommended to characterise the compartmentalisation in blood cells, to compare estimates of piperaquine pharmacokinetic parameters in plasma and whole blood and to provide information on the optimum samples for field studies in terms of drug measurement.
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An algorithm which computes the optimum sampling rate is described.
Considerable controversy exists regarding optimum sampling conditions for PMets.
Similar results are observed for the optimum sampling rate due to the space-time symmetry.
The volume of 1 L was chosen as the optimum sample volume.
Besides, the value E should lie within 10 to 20 for optimum sample size.
In addition, it does not consider the optimum sampling rate in the time domain.
Hence, the optimum sample volume has been found to be 30 μL.
However, an optimum sampling design is also subject to limitations in cost and sampling opportunities.
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