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The agency will now require the labels of oral bisphosphonates to state that the optimum duration of taking the drugs is not known.
We also want to confirm the optimum duration of annealing time.
We confirmed that the optimum duration of annealing time was 4 h.
The optimum duration of prophylaxis against venous-thromboembolism after total hip or knee replacement is uncertain.
Despite recent studies, the optimum duration of dual antiplatelet therapy (DAPT) after coronary drug-eluting stent placement remains uncertain.
The role and the optimum duration of cardiac monitoring to detect AF in patients with strokes presumed due to large vessel atherosclerosis or small vessel disease is unknown.
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The investigators concluded that neoadjuvant letrozole produced ongoing tumor shrinkage over periods up to 12 months in patients responding to letrozole at 3 Months, but that there was no optimum duration for the use of neoadjuvant letrozole.
We of course have no idea of the optimum duration for anastrozole.
Our exploratory data do not suggest that there is an optimum duration for the preoperative use of letrozole.
Five years of treatment were selected for both drugs bearing in mind the optimum duration for tamoxifen and the wish to remain blinded.
However, the calculation of the optimum duration and intensity of follow-up care among these patients requires further research.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com