Sentence examples for optimum context from inspiring English sources

This difference could be interpreted to indicate that E144R disrupts recognition of optimum context nucleotides, so that its deleterious effect on AUG recognition is dampened when the optimum context nucleotides are absent.

DOI: http://dx.doi.org/10.7554/eLife.07939.016 The E144R mutation conferred a greater increase in leaky scanning of GCN4 uAUG-1 in optimum context (∼20-fold) vs uAUG-1 in poor context (∼fourfold).

Remarkably, rps5-E144R confers a dramatic increase in leaky scanning through el.uORF1, elevating GCN4-lacZ expression by 20-fold for the construct containing optimum context (−3AAA−1) at uAUG-1.

It is possible that favorable context also contributes to the stability of PIN (Pisarev et al., 2006; Martin-Marcos et al., 2011), but the stimulatory effect of optimum context on initiation rate is not understood at the molecular level.

We agree with his/her interpretation and had actually laid the groundwork for advancing it as a likely scenario with the text in the second and third paragraphs of the Discussion that seeks to explain the increased leaky scanning observed for uAUG-1 in optimum context as the result of el.uORF1 being unstructured.

There is evidence that the context nucleotides are recognized by the α-subunit of eIF2, as replacement of heterotrimeric eIF2 with the eIF2βγ heterodimer reduced the efficiency of AUG recognition and diminished the stimulatory effect of optimum context on 48S PIC assembly in a reconstituted mammalian system (Pisarev et al., 2006).

The realization that AIDS programs have sometimes, in their single-minded zeal for results in less than optimum contexts, been misinformed and poorly planned should be taken as constructive criticism, instead of eliciting defensive responses.

The word "protocol" is used here in the context of what different monitoring programs have selected as optimum setting for analysis of filters taken at the stations within their network.

The optimal amount of choice lies somewhere in between infinity and very little, and that optimum depends on context and culture.

In this context, an optimum sizing methodology is currently developed, based on the criterion of minimum embodied energy.

55 These examples suggest that in units where the organisational culture and context supports optimum trained staff numbers, there might not be additional benefit from the use of weaning protocols compared with standardised high level approaches to weaning.