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Fuel cell polarization curves are shown, overheating and thermal inertia durations are also provided and taken into account for optimizing the regulation.
The uncertain initial states and disturbances are considered as a player doing his best to deteriorate the regulation performance from the worst-case point of view, while the system parameters to be designed are considered as another player optimizing the regulation performance under the worst-case deterioration of a former player.
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To optimize the regulation performance and SNP dose, the estimated cost function is obtained by the first self adjustable network used to design the nearly optimum controller.
Although the enhancers contained in the different lacZ reporters used in our experiments are all clearly capable of communicating with the promoter it would certainly be expected that this communication would be less efficient than for endogenous loci that contain the full complement of flanking DNA that has evolved to optimize the regulation of gene expression at this stage.
There is considerable evidence to suggest that evolution has optimized the regulation of the biomolecular networks so that they are efficient and function in a robust fashion [ 1, 34- 37].
However, we believe that it would be more effective to target Trx and CD30 together to optimize the regulation of redox and immune system functions, as by combining these systems we combine the power of redox-sensitive factors with the specificity of immune system molecules (Online Resource 1 and 2), thus opening up important new perspectives in stratified medicine.
We conclude that the topographical design of biomaterials can be optimized for the regulation of DPSC differentiation and speculate that the inclusion of ODM alters the ability of the cells to sense surface topographical cues.
We might speculate that this tendency would ultimately result in the evolution of overlapping non-coding transcripts optimized for the regulation of their protein-coding partner.
Optimizing the parameters of the regulatory system allows us to quantify the fitness benefit of regulation.
This suggests that a combination of up-regulation and downregulation of stress responsive genes may be important in optimizing the adaptation of particular biological pathways to stress conditions.
COST -- Providing the greatest benefit at the lowest cost while optimizing the cost/benefit ratio.
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CEO of Professional Science Editing for Scientists @ prosciediting.com