Adaptive designs learn from accumulating trial data in real time and apply this knowledge to optimize subsequent study execution.
There are several useful methods for finding those relevant data regions including simple nearest neighbor, or kNN, algorithms; clustering (to optimize subsequent kNN); and pruning away "bad" regions.
More specifically, improved biomarkers could help to: (1) more objectively diagnose the heterogeneous diseases, such as cocaine dependence, (2) improve signal detection to assess more efficiently small treatment effects, and (3) better characterize patient (sub populations to more efficiently test (stratify) and optimize subsequent treatment regimens.
Early detection of residual tumors or lesions with small volume may optimize subsequent therapy.
The database was designed so that the queries were optimized during the analysis process, and also to optimize subsequent analysis of the results.
Collectively, these data suggest that a minimal impulse acts to prepare tachyzoites for invasion, possibly by promoting apex positioning, and/or rhoptry fusion [ 33] to optimize subsequent release of the RON complex into the PM.
In situations where highly specific assays are available, such as core-binding factor AML, MRD is the most important prognostic factor for relapse prediction even when high-risk clinical features and pre-treatment molecular risk stratification markers are considered, and can be used to optimize subsequent treatment.
When prediction errors are detected and firing rates change, the prefrontal cortex may not only integrate the signal within its recurrent (working memory) intrinsic circuitry, but it may have a key restorative function in efferent structures such that the firing rates return to a baseline tonic level that optimizes subsequent responsiveness to input.
Wrapper methods measure the usefulness of feature subsets according to their predictive power, optimizing the subsequent induction procedure that uses the respective subset for classification [51, 60, 61, 62, 63].
Purification of the block copolymers was carried out via several methods in order to optimize their subsequent characterization.
