Sentence examples for optimizing sequences for from inspiring English sources
We present a new method of producing optimizing sequences for highly symmetric functionals.
Burke and Willis [ 76] got motivated from works of Joyce and colleagues who were the first to use point mutations through error-prone amplification and thus to optimize sequences for particular functions [ 77– 81].
Hence, based on the promising in silico validation results which implicate CC as an important design parameter for optimizing sequences, the newly developed CCO procedure can potentially supersede the ICU optimization techniques currently implemented in gene design software tools.
Among Illumina library preparation options, transposon-based libraries diverged from all others and adaptor ligation was a critical step for optimizing sequencing yields.
Although MOSAIC directly optimizes sequence identity, this result is noncircular for two reasons.
This finding should be considered when optimizing coding sequences for use in biotechnological applications.
In short, MetCap is a web-based probe-designing pipeline that takes user's sequences of interest and design probes for targeting those sequences optimized for sequence capture.
The method samples sequence and structure space in the vicinity of a known sequence and structure by alternately optimizing the sequence for a fixed protein backbone using rotamer based sequence search, and optimizing the backbone for a fixed amino acid sequence using atomic-resolution structure prediction.
These include algorithms for designing novel ligand-binding sites and simultaneously optimizing a sequence for multiple target structures.
We can enhance binding specificity of a protein by computationally optimizing its sequence for better interactions with one target and worse interaction with alternative target(s).
Contrary to the conventional practice which adopts ICU optimization as the key element of gene design, our study suggests that CC fitness is a more relevant design parameter for optimizing the sequence for improved heterologous protein expression.
