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Optimizing benefit packages in public health insurance is as important as expanding coverage, both for health care financing and for utilization management as well.
How best to use the current treatment in terms of optimizing benefit while minimizing unnecessary treatment and toxicity is therefore a highly relevant clinical questions.
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Unfortunately use of antibiotics has inherent risks and costs and optimizing benefits is especially difficult in the midst of bioterrorist events.
Early phase clinical trials frequently combine targeted agents to optimize benefit.
In light of the modest benefits obtained with transplantation of rodent astrocytes isolated directly from the immature CNS [49] [53], however, our present and earlier studies [14], [57] suggest that it is necessary instead to transplant astrocytes generated from precursor cells in vitro in order to optimize benefit.
The majority of GPs considered that, to optimize benefit for patients, such courses should be integrated in a comprehensive therapeutic plan.
Taken together, these findings provide experimental evidence in humans to support aggressive normalization of plasma glucose using insulin in patients with T1DM who experience repeated bouts of ischemia, in order to optimize benefit from insulin-induced protection and endogenous protection by ischemic preconditioning.
In addition, because of its psychoactive side effects, difficulty in dose titration to optimize benefit, minimize side effects like dizziness, dysphoria, depression, hallucinations, alteration in psychomotor function and paranoia, time to response and long-term effects when taken orally limits the use of this agent for all cancer patients with symptoms of cancer anorexia [ 41].
Taken together, these data provide human experimental evidence for aggressive normalization of plasma glucose in patients with T1DM who experience repeated bouts of ischemia, such as angina pectoris or transient ischemic attacks, in order to optimize benefit from endogenous protection by ischemic preconditioning.
In two experimental studies, I identify conditions in which consultant recommendations and, in turn, manager MCS choices intend to benefit management rather than optimize benefits for the firm.
Thus, our study suggests that a better adherence to antihypertensive agents is related to a risk reduction of ESRD and this adherence needs to be improved to optimize benefits.
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