This optimized combined stimulation was then used to promote function after PTX because it enhanced functional connections between M1 and spinal circuits and greater M1 engagement in muscle contraction than either stimulation alone.
We hypothesize that chondrocytes from distinct zones of articular cartilage respond differently to compressive loading, and that zonal chondrocytes from osteoarthritis (OA) patients can benefit from optimized compressive stimulation.
Importantly, the results of this study reveal that systemic and readily controllable cues, such as scaffold alignment and optimized mechanical stimulation, are sufficient to drive MSC differentiation, without the need for additional chemical stimuli.
Previous in vivo imaging studies have reported astrocytic Ca2+ surges upon optimized sensory stimulation [16] or running behavior [17] and the existence of spontaneous astrocytic Ca2+ surges in juvenile rats (
The co-applications of rice bran, K2HPO4 and urea under optimized bio-stimulation conditions significantly increased the production of gases, acids and emulsifiers.
The optimized bio-stimulation conditions were quantified with response surface methodology (RS M experiments based on a Box Behnken design (Chen et al. 2007).
The experimental surface tension (40.6 mN/m) under the optimized bio-stimulation conditions agreed well with the predicted value, which the predicted minimum surface tension (38.6 mN/m) was also obtained under the optimal bio-stimulation conditions.
