Sentence examples for optimized interaction from inspiring English sources
Feature-based MIFs allowed for the manual creation of virtual compounds that fulfill an optimized interaction pattern, which led to a 3D pharmacophore that was used for a second virtual screening to select compounds for biological testing.
We describe in detail a general approach to de novo design of protein interactions based on computed, energetically optimized interaction hotspots, which was recently used to produce high-affinity binders of influenza hemagglutinin.
We finally demonstrated that the MjTyrRS mutants obtained in this study, when paired with a previously evolved MjtRNACUATyr (MjtRNACUATyr-Nap1) that has optimized interaction with E. coli EF-Tu, further improved amber suppression efficiency.
Results also indicate a possibility that such optimized interactions provide structural determinants for enhanced stability of proteins from thermophilic organisms.
The PLN were prepared by using a rationally selected composition that was found in our previous work to provide optimized interactions of verapamil hydrochloride (VRP) with dextran sulfate sodium (DS) and then the VRP DS complex with dodecanoic acid (DA).
We show that the multi-targeted, IAPP, amyloid-β, and α-synuclein, binding properties of β-wrapins originate mainly from optimized interactions between β-wrapin residues and sets of residues in the three amyloidogenic proteins with similar physicochemical properties.
This study may provide useful guidelines for design of novel potent inhibitors with optimized interactions.
Similar but more optimized interactions than in the iododiflunisal complex are observed for the iodine atom in both crystal structures of 23b and 22b complexes.
This study presents a microscopic picture at atomistic details for explaining the large difference in the dissociation rate constant among different inhibitors, which might provide important guidelines for design of the novel potent inhibitors with optimized interactions.
Screening of libraries selects for optimized interactions.
To assure the reliability of the protein-protein interactions, we used only the interaction data that was supported by experimental evidence and not the optimized interactions.
