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The optimized formulation was selected through numeric optimization approach.
The optimized formulation was identified and validated for its performance by using numerical optimization technique.
The optimized formulation was calculated and examined.
An optimized formulation was prepared and evaluated for individual responses.
Furthermore, physicochemical characterization of the optimized formulation was performed.
Pharmacokinetic parameters were calculated after performing the in vivo studies of best optimized formulation in rats.
In vitro release study showed prolonged drug release from the optimized formulation following Korsmeyer Peppas model.
Desirability function scrutinized by design-expert software for optimized formulation was 0.920.
The optimized formulation provided %entrapment and %release, which were close to the predicted values.
Selection of the optimized formulation was done using desirability function and overlay contour plots.
Tmax and mean residence time were significantly higher from optimized formulation vis a vis suspension.
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