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Here we present a novel information rate estimator without these limitations that is also optimized for computational efficiency.
Methods that are optimized for computational speed that also correct for multiple tests appropriately given linkage disequilibrium and non-independent multilocus models under consideration are needed to effectively search the genome for gene-gene interactions.
Limitations of the convolution approach are discussed, as are possible techniques for decreasing computational expense and areas for future work.
For this reason of computational expense, the RNAshapes program also provides two heuristics: one is a low probability filter that excludes subshapes of very low probability, e.g. <10−6.
Accuracy is significantly improved for similar computational expense.
The other crucial challenge is that the huge search space for an optimal combination of classifier genes renders high computational expenses [20].
As a computational expenses, both approaches require memory space for loading the entire all-pairwise distance matrix.
Due to computational expense most web servers for protein domain search only provide a single-sequence submission interface [ 8, 9].
However, the coupled model of large-scale simulation problems usually encounters large matrix system and high computational expenses, where the time stepping is a crucial factor for numerical stability and computational efficiency.
This reduces the computational expenses.
We conclude that 498 K simulations are suitable for elucidating the details of protein unfolding at a minimum of computational expense.
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