Sentence examples for optimized efficacy and from inspiring English sources

Oral modified release (MR) dosage forms are developed by altering the kinetics and site of drug release and absorption in order to achieve specific clinical objectives, such as improved patient compliance, optimized efficacy, and reduced adverse events.

Nevertheless, the narrow therapeutic range and great interindividual variability of amikacin in all patients emphasize the need for therapeutic drug monitoring of its peak and trough levels for optimized dosing as well as optimal efficacy and prevention of serious side effects.

By attaching sialic acid onto the terminal galactoses of biantennary protein N-glycans, ST6Gal-I facilitates protein remodeling towards a humanized glycosylation and thus optimized efficacy in pharmacological use.

The use of jet nebulizers appears to be predominant, and practical implementations were far from the optimized efficacy conditions described above.

The most potent compounds (1.2 1.3-fold the CQ on the W-2 strain) can be considered as promising 'lead compounds' to be further optimized to improve efficacy and selectivity against Plasmodia.

Emission control (e.g., optimization of treatment options in wastewater management) and drug development (i.e., designing pharmaceuticals that are optimized for both efficacy and degradability) depend largely on scientific research and technological capabilities.

For clinical practice, categorical CTC-counts may provide complementary information towards individualized treatment strategies with early prediction of treatment efficacy and optimized sequential treatment.

This suggested that compound 15q is a moderately potent and selective hit molecule which can be further optimized structurally to increase the efficacy and overall pharmacological profile as DPP-4 inhibitor.

Starting from eight different layouts, the chamber geometry was computationally optimized for maximizing the single cell trapping efficacy and then integrated in a polydimethylsiloxane (PDMS) microfluidic device.

Each component of the ADC (the antibody, linker and drug) must also be optimized to fully realize the goal of a targeted therapy with improved efficacy and tolerability.

In these studies, patients randomized to LDX were individually optimized to LDX 30, 50, or 70 mg/day during weeks 1 4 based on efficacy and tolerability [ 25, 27, 28].