To increase trypanosome yields we designed an optimized culture medium by addition of supplemental compounds.
This result is further optimized by the addition of other rare earth elements.
The optimized formula was subjected to modification by addition of different proteoglycans, as a compensatory treatment, to improve its pharmacological properties.
Based on the same principle an inducible system has been developed where the catalytic domain of caspase-9 is fused to a modified FK506-binding domain (FKBP) that can be homodimerized by addition of an optimized chemical inducer of dimerization (CID) AP20187 [ 12].
An optimized enzyme mixture containing 16 components (by addition of α-glucuronidase, a GH11 endoxylanase [EX2], Cel5A, Cel61A, Cip1, Cip2, β-mannanase, amyloglucosidase, α-arabinosidase, and Cel12A to the core set) was determined for AFEX-pretreated corn stover, DDGS, and AP-pretreated corn stover.
Within this work, the TiCxN1 − x coatings have been further optimized with respect to their structure and mechanical properties by addition of BCl3 to the feed gas.
The effect of varying the phosphate concentration by addition of sodium phytate and KH2PO4 using the optimized media formulation with 1% GrCf was thus studied.
The PBPK model then evolved by addition of the newly generated nonclinical data, and this optimized model was used to propose the mechanism of the dose-dependent and time-dependent PK nonlinearity.
The DNA extraction procedure was optimized to minimize artificial induction of 8- oxodG, by using radical-free phenol, minimizing exposure to oxygen and by addition of 1 mM deferoxamine mesylate and 20 mM TEMPO (2,2,6,6-tetramethylpiperidine-N-oxyl 2,2,6,6-tetramethylpiperidine-N-oxyl 2,2,6,6-tetramethylpiperidine-N-oxyl 2,2,6,6-tetramethylpiperidine-N-oxyl
