Sentence examples for optimized analog from inspiring English sources
The pharmacokinetic properties of an optimized analog (9) were characterized in several preclinical species, demonstrating pharmacokinetic characteristics suitable for once-a-day dosing in humans.
The overall potency of our inhibitors towards TgCPL was improved from 2 μM to as low as 110 nM and we successfully demonstrated that an optimized analog 18b is capable of crossing the BBB (0.5 brain/plasma).
An optimized analog of dorsomorphin, LDN-193189, inhibited the development of atheroma in low-density lipoprotein (LDL -receptor-deficient mice (Cuny et aLDL -receptor-deficient., 2012).
Once the top endothelial layer is fully optimized, analog phenomena to tumor angiogenesis and metastasis can be studied in our 3D microfluidic cell arrays.
However, ELND006, a lead optimized analog derived from ELN475516, was well tolerated for three and six months in a chronic PDAPP mouse study at doses which affected AD pathology in the absence of any toxicity [ 76].
Methotrexate (Sigma-Aldrich, St . Louis MO, USA), infliximab (Remicade, Schering-Plough Labo N.V., Belgium), celecoxib (Pfizer Inc, New York, NY, USA), and antiflammin-2 (custom synthetised peptide) were used as comparators to the lead anti-inflammatory peptide P-NT.II and optimized analog PIP-18.
Even optimized analogs less prone to proteolysis have to be applied at least daily or once-weekly utilizing microsphere formulations or fusion to proteins.
No study to date has evaluated the efficacy of RT-CGM in combination with CSII or optimized analog-based multiple daily injections (MDIs) with the primary objective of reversing IAH.
Such platform consists in a wide set of optimized high-performance analog, digital, and software intellectual property (IP) modules for various kinds of sensors.
The system, developed according to a platform-based design approach, consists in a set of optimized high-performance analog, digital, and software IP modules that can interface to several kinds of sensors.
