The aim of this study was to know how caregiver burden was influenced by caregivers' and patients' characteristics and by social support; the intention was to use these elements in order to suggest how to optimize the interventions which may reduce caregivers' subjective feeling of burden.
Second, the diagnostics for monitoring the effects of lifestyle change and optimizing the intervention are the same as the screening diagnostics.
A better understanding of the various factors contributing to the efficacy of treatment is essential for the development of interventions to optimize the treatment of chronic phase CML (CP-CML) with a protein kinase inhibitor like nilotinib.
Here are some examples for possible deliberate interventions on the three objects to influence and optimize the fit: Intervention on the individual level: user involvement in system selection and introduction (change management), user training sessions, good user support, motivation by the management (leadership issues).
In those situations, different genetic defects may be involved so both the genotype and the phenotype must be characterized to apply the appropriate treatment and, as a minimum, the degree of insulin resistance, beta-cell capacity, degree of autoimmunity, gene variants, and the metabolic profile must be measured in newly diagnosed T2D patients to optimize the therapeutic intervention.
A thorough formative evaluation of the workplaces to evaluate the workplace readiness for this intervention and to optimize the tailoring of the intervention to the specific needs and resources at each workplace [ 34, 37, 38], will be made before the start of the intervention using NPT.
Before development and implementation of a complex intervention, a comprehensive needs assessment is necessary [ 35, 36], to optimize the tailoring of the intervention content and implementation to the specific needs and resources at each workplace [ 34, 37, 38].
During the initial phase, relevant theory is explored to optimize the choice of intervention and to predict major confounders.
In addition a participatory component is recommended in needs assessments, to evaluate the workplace readiness for change and to optimize the tailoring of the intervention to the specific needs and resources at each workplace [ 34, 37, 38].
