It could, for example, be applied to determine the potential of the PBR for resisting nuclear-weapons proliferation and to optimize proliferation-resistant features.
The supplementation of the conditioned medium with EGF further optimized proliferation and mitochondrial activity of the cervical epithelial cells.
When cells could optimize their proliferation under restricted resources, cell migration rates evolved to even higher levels than before.
Experiments were carried out to optimize the callus proliferation using factors like temperature (10, 20, 25 °C), and 5 chemical elicitors viz.
Not all mitogen concentrations and stimulation durations were tested on all available samples because the samples collected during the 2001 sampling season were also used to optimize the lymphocyte proliferation assay.
All change and all versions that reflect change must be implemented in a consistent manner with minimal impact to consumers, must be optimized to avoid proliferation of one-off services, and must be tested to ensure the framework is operational and effective.
We found that when hES cell derived hepatic endoderm cells were plated on mitomycin-treated murine embryonic stromal feeders (STO) and cultured in hepatic progenitor expansion medium —a serum-free medium optimized for the proliferation of progenitor cells from rat hepatocytes [18] parenchymal cell colony appeared (Figure 3A and B).
IL-2 signaling critically optimizes lymphocyte differentiation, proliferation, and survival (Williams et al., 2006; Bachmann et al., 2007; Pipkin et al., 2010; Liao et al., 2011; McNally et al., 2011; Boyman and Sprent, 2012).
Because of their intrinsic effects on NK cells, addition of IL-21 to IL-2 or IL-15 would be the best combination to optimize the ex vivo proliferation of NK cells.
Through this process, the phenotype of a previously differentiated cell reverts to the phenotype of a facultative anaerobic, heterotrophic cell optimized for survival and proliferation in primordial hypoxic environments.
We highlight that in our simulations mitochondria-derived citrate constitutes a fundamental metabolite to be optimized for supporting cell proliferation.
