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Poly-ADP-ribose-polymerase inhibition sensitizes tumor cells to cytotoxic agents, which induce DNA damage, including cyclophosphamide (C), and metronomic dosing of C may optimize potential for synergy.
We provide evidence showing that GAG mimetics may have great interest for cell therapy applied to vascular regeneration therapy and represent an alternative to exogenous growth factor treatments to optimize potential therapeutic properties of ECFC.
Adaptive behavior requires that animals form decisions that optimize potential rewards and minimize potential punishment [1], [2], [3].
Although these interrelations are not completely understood, it does suggest that knowledge on distribution profiles of LCFA transporters in combination with those of sterol transporters is needed to optimize potential intervention strategies to lower sterol absorption.
In order to optimize potential chemotherapeutic prodrug esters it is important to characterize and identify any differentially expressed esterases.
As these new agents enter the clinic, nurses and other health care providers will require an understanding of the unique efficacy and safety profiles with immunotherapy to optimize potential patient benefits.
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The Optimized Potential for Liquid Simulations (OPLS) all atom force field (Jorgensen et al., 1996) is uniformly utilized within the Q-MOL program.
A Nose-Hoover thermostat [22] was used to maintain the temperature at 300K, and a Tip3P water model with OPLS (Optimized Potential for Liquid Simulations) force field was adopted [13], [14].
Desmond Molecular Dynamics System [ 23, 24] with Optimized Potential for Liquid Simulations [ 25, 26] all atom force field was used to study the dynamic stability of the complex.
All docking simulations used the OPLS (Optimized Potentials for Liquid Simulations) force field [ 30], and used Schrödinger's IFD (Induced Fit Docking) package [ 31].
To parameterize lipid molecules, the OPLS-AA (Optimized Potentials for Liquid Simulations-All Atom) force field was used with recently derived parameters for the long hydrocarbons, glycerol backbone and head group (so-called MACROG lipids) [16].
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