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The aim of asthma treatment has been to minimize symptoms, optimize lung function, and prevent acute episodic deterioration (exacerbations), by lung function assessment.
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Treatment is aimed at optimizing lung function, nutritional repletion, aerobic exercise training, and (in certain patients) oxygen therapy.
The authors tested a global strategy of optimizing lung function to successfully harvest twice as many lungs according to standard eligibility criteria (including a PaO2/FiO2 ratio of greater than 300 mm Hg).
"Patients have poor lung function, and you help them by taking out part of their lungs".
Lung function and cardiac function were also assessed.
Intrauterine inflammation alters lung development to improve postnatal lung function and may predispose the infant to lung and brain injury.
In IPF lungs, HOPX expression was decreased in whole lungs and significantly correlated to a decline in lung function and progression of IPF.
Lung function and chest wall expansion were reduced on average.
The Lancet study says: "By sampling from the extremes of the lung function distribution in UK Biobank, we identified novel genetic causes of lung function and smoking behaviour.
"Long-term exposure to air pollution suppresses lung function and leads to vulnerability through life.
Alimta improved the symptoms of many patients by reducing pain, improving lung function and easing breathing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com