Therefore, further studies are needed in order to improve the serum stability of CaIX-P1, optimize its binding efficacy and lead to generation of peptide-based ligands, which can be used for targeting human carbonic anhydrase IX and tumor hypoxia.
Over the last few years, focus has been placed on the development of the new prolonged-release, once-a-day formulation of trazodone, with the aim to optimize its antidepressant efficacy, and improve the treatment schedule and compliance in MDD patients.
To enhance its antitumor efficacy and optimize its safety, we manipulated the wE1a gene and designed a 720-bp truncated minimal-E1a (mE1a) by deletions and mutations of amino acid residues.
Regardless of the humoral or cellular immunity elicited by vaccines, relevant markers are needed to evaluate the vaccine efficacy and/or to optimize its development.
Nevertheless, to translate this potential into a broad new family of therapeutics, it is necessary to optimize the efficacy of the RNA-based drugs [ 13].
It is common to optimize the efficacy of PPTT by neglecting the effects of multiple scattering by the nanoparticles and light diffusion through biological tissue [ 2, 7, 10– 16, 16, 22, 25, 26, 35].
Due to its multifunctional pharmacology, appropriate dosing is indeed crucial to optimize clinical efficacy in patients with MDD.
Therefore, the optimal number of chemotherapy cycles and the tumor response after chemotherapy that optimize the efficacy of chemotherapy should be examined.
Multifunctional theranostics have recently been intensively explored to optimize the efficacy and safety of therapeutic regimens.
Other top pharmaceutical and biotechnology companies including Genentech, Amgen, Pfizer, and Merck also have an ongoing need for pharmacometric skills to optimize drug efficacy and minimize potential toxicities.
