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Full sequence information on even a large number of people with and without disease will not easily yield the sought-after risk information; indeed, the quantity and quality of phenotypic and environmental data required to optimize interpretation of the genomic data remains unknown and may well greatly exceed the complexity of the genomic data.
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This approach optimizes interpretation in terms of the correlations between each item and each factor.
For both tests, human papillomavirus test, study setting and age affected sensitivity or specificity of the smear test (spectrum effect), but only human papillomavirus test and study setting modified the likelihood ratios (spectrum bias) for clinical reading, whereas only human papillomavirus test and age modified the likelihood ratios (spectrum bias) for "optimized" interpretation.
Important changes in the research process are needed to allow efficient translation of preclinical discoveries to the clinic, including improvements in the laboratory and publication practices involving animal research and early incorporation of human proof-of-concept studies to optimize the interpretation of animal data for its predictive value for humans and the design of clinical trials.
To optimize the interpretation process, investigator triangulation was applied.
BAF contributed original concepts regarding the evolutionary origins and role of polydnaviruses in endoparasitoid biology, provided virological expertise to optimize data interpretation, and participated in writing the manuscript.
To optimize quantitative interpretation, various possibilities must be considered, the first of which is improving our knowledge of xenobiotic distribution in VH.
In 2010, to get a sense of the baseline seroprevalence rate in a seemingly lower-risk population and to optimize the interpretation of the microneutralization assay results, we obtained samples from a group of nonpoultry workers.
With the large amount of data that is being gathered in the different national survey projects, and which is expected to become available in Europe in the near future through the expected European Pilot Project on HBM, a framework to optimize data interpretation from such survey projects may greatly enhance the usefulness of HBM data for risk managers and policy makers.
However, within the vast amount of data that is being gathered in the different national survey projects, and which is expected to become available in Europe in the near future (see further), a framework to optimize data interpretation from such survey projects may greatly enhance the usefulness of HBM data for risk managers and policy makers.
The results of the present study provide us with a tool to optimize the interpretation of CFQ-scores in young patients with CF. Clinicians should be aware that the perception of health-related quality of life is not as disease-specific as one might think and also relies on factors such as age, maturation and gender.
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CEO of Professional Science Editing for Scientists @ prosciediting.com