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The response surface methodology is employed to optimize formulations for antibacterial activity.
Future work is directed to optimize formulations for in vivo ocular gene delivery.
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An important part of drug development is to optimize formulation for a given biotherapeutic.
Four DoE models were applied to optimize formulation parameters for the preparation of pH sensitive nifedipine nanoparticles.
This paper reports a 33 full factorial design study to optimize SLNs formulations for hydrophilic biomolecules.
The objective of the present investigation was to prepare chitosan solid lipid nanoparticles (SLN), containing sumatriptan succinate using solvent injection method and to optimize the formulations for brain targeting potential.
The objective of this study was to evaluate the effect of two factors (ratio of Eudragit S100 and Eudragit L100 and the coating level) on indomethacin release from pellets in order to optimize coating formulations for colonic delivery.
It was also an objective to optimize formulation parameters and evaluate developed formulation for its in vitro, ex vivo and in vivo performances.
In a previous study, we developed a method for optimizing formulations to aid in the delivery of plasmid DNA in the process of nucleofection [ 10].
CMCOF and GelTAOF optimized formulations represent two suitable oral delivery systems for immediate and controlled release, respectively.
In addition, the D-optimal mixture experimental design was used to optimize the optimal formulation of probiotic bacteria for denitrification process.
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