Stepping into her pristine, uber-organized house, it was apparent that she'd done everything possible to optimize exposure to the breathtaking vistas surrounding the property, even to the point of never hanging any window shades whatsoever.
Thus, under these particular circumstances, the principle of how to optimize exposure assessment was not sensitive to the cost model, even if the eventual size of the data set allowed by budget constraints was influenced by non-linearities in subject recruitment costs.
Similar to the issue of cost function sensitivity discussed above, the principle of how to optimize exposure assessment seem, however, to be very robust to changes in unit costs and variance components when between-subject variability is large compared to within-subject variability and subject recruitment costs are small or similar to costs for setting up measurement occasions (table 2).
For example, multiple (linear) regression methods have been used to optimize exposure model parameters for a subsample of subjects with measured exposures, and then model-based predictions are extrapolated to larger groups of subjects with no measured exposures.
Administering two times the dose neither doubles the time above the MIC nor optimizes exposure to the antibiotic, but it does increase the cost of therapy.
➢ Face Detection: Reduce the chance of blurred subjects in images by recognizing up to eight faces, tracking them within the image area, and automatically focusing and optimizing exposure for sharp portraits.
In view of the diverse and unique pharmacokinetic profile of drugs in this patient population, there is increasing use of therapeutic drug monitoring (TDM) in attempt to optimize the exposure of antibiotics, improve clinical outcome and minimize the emergence of antibiotic resistance.
Regardless, to handle this threat, selective pressure imposed through inappropriate polymyxin usage should be reduced through standardizations of prescribing policies, and optimizing exposures when polymyxins are warranted.
The importance of optimizing exposure time to CPA in order to allow adequate penetration of CPA, whilst minimizing CPA toxicity, was clearly illustrated in this study by the difference in ovarian function observed between ovaries infused with CPA for either 10 or 60 min prior to WOCP.
